The Black Stars will face the Super Eagles of Nigeria as both sides battle for a spot at the 2022 FIFA World Cup scheduled to be held in Qatar.
The play-off draw for the African Qualifiers was held in Douala with ten Group winners from Round Two pairing with others.
The Black Stars who have appeared at the World Cup three times will host Nigeria in a First Leg Encounter on March 25, with the Second Leg slated four days later.
The Super Eagles who have had a stellar outing at the ongoing AFCON 2021, would be hoping to book a place at the World Cup for the seventh time, having made their debut in 1994.
The Black Stars on the other hand, would be looking to put behind their disappointment at the AFCON, and book a place at the world’s football showpiece.
Other fixtures of the playoff include Egypt against Senegal, Cameroon will play Algeria, DR Congo will come up against Morocco and Mali will battle it out with Tunisia.